Product Name :ARHGEF40 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Rho guanine nucleotide exchange factor 40: Acts as a guanine nucleotide exchange factor (GEF) for RHOA and RHOC . Promotes actin stress fiber formation, force-induced stress fiber reinforcement and organization of KRT8/KRT18 networks via activation of RHOA/ROCK signaling, which is mediated by N-terminus KRT18 binding . Regulates the formation or maintenance of properly elongated morphology of epithelial tubules, via mediation of the organization and orientation of KRT18 filaments (By similarity). Promotes RHOA-dependent, cell-cell contact mediated reorientation of endothelial cells and their actin stress fibers in response to mechanotransduction . Positively regulates hemidesmosome formation via acting as a linker protein that anchors keratin filaments to hemidesmosomes . Also required for JUP localization at cell-cell adhesion junctions
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ARHGEF40 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SOLO; Rho guanine nucleotide exchange factor 40; Protein SOLO
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ARHGEF40.
Modification :Unmodification
