Product Name :ATAD5 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :ATPase family AAA domain-containing protein 5: Has an important role in DNA replication and in maintaining genome integrity during replication stress . Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis . Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis . Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway . As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle . This seems to be dependent on its ATPase activity . Plays important roles in restarting stalled replication forks und...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ATAD5 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C17orf41; FRAG1; ATPase family AAA domain-containing protein 5; Chromosome fragility-associated gene 1 protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ATAD5.
Modification :Unmodification
