Product Name :RECQL5 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :ATP-dependent DNA helicase Q5: DNA helicase that plays an important role in DNA replication, transcription and repair . Probably unwinds DNA in a 3'-5' direction (Probable) . Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability . Also associates with POLR1A and enforces the stability of ribosomal DNA arrays . Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress . Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis . Required for efficient DNA repair, including repair of inter-strand cross-links . Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds prefer...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of RECQL5 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :RECQ5; ATP-dependent DNA helicase Q5; DNA helicase, RecQ-like type 5; RecQ5; RecQ protein-like 5
Immunogen :A synthetic peptide encompassing a sequence within the center region of human RECQL5.
Modification :Unmodification
