Product Name :TULP3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Tubby-related protein 3: Protein-protein adapter that drives transport of G protein-coupled receptors into primary cilia by mediating association between the intraflagellar transport complex A (IFT-A) and G protein-coupled receptors FFAR4, GPR45 and GPR161 . Acts as a negative regulator of the Shh signaling by promoting trafficking of GPR161 to cilia . During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes . Promotes transport of GPR45 into primary cilia of neurons in paraventricular nucleus (PVN) of the hypothalamus (By similarity). Binds to phosphorylated inositide (phosphoinositide) lipids; both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking . Besides its role in cilium localization, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds lithocholic acid, a me...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TULP3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TUBL3; Tubby-related protein 3; Tubby-like protein 3
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TULP3.
Modification :Unmodification
