Product Name :BHLHE22 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Class E basic helix-loop-helix protein 22: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of BHLHE22 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :BHLHB5; TNRC20; Class E basic helix-loop-helix protein 22; bHLHe22; Class B basic helix-loop-helix protein 5; bHLHb5; Trinucleotide repeat-containing gene 20 protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human BHLHE22.
Modification :Unmodification
