Product Name :H2AFB1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Histone H2A-Bbd type 1: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability . Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo . They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase . They associate with spliceosome components and are required for mRNA splicing
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of H2AFB1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Histone H2A-Bbd type 1; H2A Barr body-deficient; H2A.Bbd
Immunogen :A synthetic peptide encompassing a sequence within the center region of human H2AFB1.
Modification :Unmodification
