Product Name :BEX2 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Protein BEX2: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer . Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA . Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A . Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity . In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of BEX2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Protein BEX2; Brain-expressed X-linked protein 2; hBex2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human BEX2.
Modification :Unmodification
