Product Name :PUS10 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :tRNA pseudouridine synthase Pus10: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm . In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs . tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs . Does not show tRNA pseudouridylate synthase activity in the nucleus . In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity . Binds pri-miRNAs . Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage . Required for the progression of the apoptotic signal through intrinsic mitochondri...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of PUS10 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CCDC139; DOBI; Putative tRNA pseudouridine synthase Pus10; Coiled-coil domain-containing protein 139; tRNA pseudouridine 55 synthase; Psi55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase
Immunogen :A synthetic peptide encompassing a sequence within the center region of human PUS10.
Modification :Unmodification
