Product Name :SPATA2 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :Spermatogenesis-associated protein 2: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-induced necroptosis . Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) . Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD . Controls the kinase activity of RIPK1 and TNF-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SPATA2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0757; PD1; Spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SPATA2.
Modification :Unmodification
