Product Name :SDHAF1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :Succinate dehydrogenase assembly factor 1, mitochondrial: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol . Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants . May act together with SDHAF3 . Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SDHAF1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :LYRM8; Succinate dehydrogenase assembly factor 1, mitochondrial; SDH assembly factor 1; LYR motif-containing protein 8
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SDHAF1.
Modification :Unmodification
