Product Name :HMBOX1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Homeobox-containing protein 1: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination . Might also be involved in the DNA damage response at telomeres
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of HMBOX1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Homeobox-containing protein 1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human HMBOX1.
Modification :Unmodification
