Product Name :HELZ2 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :3'-5' exoribonuclease HELZ2: Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response . Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities . Shows a strong preference for pyrimidine over purine residues for its nuclease activity . Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA . In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion . Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine-rich protein SFPQ and THRAP3
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of HELZ2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1769; PRIC285; Helicase with zinc finger domain 2; ATP-dependent helicase PRIC285; Helicase with zinc finger 2, transcriptional coactivator; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PDIP1; PPAR-gamma DBD-interacting protein 1; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human HELZ2.
Modification :Unmodification
