Product Name :MRGPRE polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :Mas-related G protein-coupled receptor member E: G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis . Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity . In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA . Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of MRGPRE protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :GPR167; MRGE; Mas-related G-protein coupled receptor member E; G-protein coupled receptor 167
Immunogen :A synthetic peptide encompassing a sequence within the center region of human MRGPRE.
Modification :Unmodification
