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GPR35 polyclonal antibody

货号: BS35370

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS35370

Product Name :GPR35 polyclonal antibody

Swiss-Prot :Q9HC97

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB, IF/ICC

Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

Background :G protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase . GPR35 can couple with G(i)/G(o)- or G(12)/G(13) classes of G alpha proteins depending on the context, mediating the inhibition of adenylate cyclase or activation Rho small GTPases, respectively . KYNA-binding promotes monocyte adhesion to vascular endothelium under flow conditions, leading to G(i)/GNAI1 activation and inhibition of adenylate cyclase . Involved in cardioprotection during ischemia by pr...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GPR35 protein

BiowMW :~34.1 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :G-protein coupled receptor 35; Kynurenic acid receptor; KYNA receptor

Immunogen :A synthetic peptide encompassing a sequence within the center region of human GPR35.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Pim-1 expression in Jurkat (A) whole cell lysates.

免疫沉淀（IP）