Product Name :ABHD2 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)
Background :Monoacylglycerol lipase ABHD2: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane . Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) . Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester . Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation . May also play a role in smooth muscle cells migration (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ABHD2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :LABH2; Abhydrolase domain-containing protein 2; Lung alpha/beta hydrolase 2; Protein PHPS1-2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ABHD2.
Modification :Unmodification
