Product Name :SLC46A1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force . Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic pH via alternate outward- and inward-open conformation states . Protonation of residues in the outward open state primes the protein for transport . Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate . Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases . Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes . Al...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SLC46A1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :HCP1; PCFT; Proton-coupled folate transporter; G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SLC46A1.
Modification :Unmodification
