Product Name :ATP9A polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Probable phospholipid-transporting ATPase IIA: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation . Also involved in endosome to trans-Golgi network retrograde transport . In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation . Appears to be implicated in intercellular communication by negatively regulating the release of exosomes . The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved . Required for the maintenance of neurite morphology and synaptic transmission (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ATP9A protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ATPIIA; KIAA0611; Probable phospholipid-transporting ATPase IIA; ATPase class II type 9A
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ATP9A.
Modification :Unmodification
