Product Name :HELB polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :DNA helicase B: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection . Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB . As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation . Acts independently of TP53BP1 . Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates . During S phase, may facilitate cellular recovery from replication stress
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of HELB protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DNA helicase B; hDHB
Immunogen :A synthetic peptide encompassing a sequence within the center region of human HELB.
Modification :Unmodification
