Product Name :GLTSCR2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Ribosome biogenesis protein NOP53: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis . In ribosome biogenesis, may also play a role in rRNA transcription . Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions . DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation . It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation . Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of GLTSCR2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Glioma tumor suppressor candidate region gene 2 protein; p60
Immunogen :A synthetic peptide encompassing a sequence within the center region of human GLTSCR2.
Modification :Unmodification
