Product Name :FAM175B polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :BRISC complex subunit Abraxas 2: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates . May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm . Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of FAM175B protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ABRO1; KIAA0157; BRISC complex subunit Abro1; Abraxas brother protein 1; Protein FAM175B
Immunogen :A synthetic peptide encompassing a sequence within the center region of human FAM175B.
Modification :Unmodification
