Product Name :MAML1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Mastermind-like protein 1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of MAML1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0200; Mastermind-like protein 1; Mam-1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human MAML1.
Modification :Unmodification
