Product Name :PELI2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :E3 ubiquitin-protein ligase pellino homolog 2: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of PELI2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human PELI2.
Modification :Unmodification
