Product Name :SMG8 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Nonsense-mediated mRNA decay factor SMG8: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SMG8 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ABC2; C17orf71; Protein SMG8; Amplified in breast cancer gene 2 protein; Protein smg-8 homolog
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SMG8.
Modification :Unmodification
