Product Name :LEMD2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :LEM domain-containing protein 2: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis . Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation . Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase . During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing . Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of LEMD2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :LEM domain-containing protein 2; hLEM2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human LEMD2.
Modification :Unmodification
