Product Name :NUDT3 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Diphosphoinositol polyphosphate phosphohydrolase 1: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . InsP6 (inositol hexakisphosphate) is not a substrate . Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates . The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility . Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppR...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of NUDT3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DIPP; DIPP1; Diphosphoinositol polyphosphate phosphohydrolase 1; DIPP-1; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3
Immunogen :A synthetic peptide encompassing a sequence within the center region of human NUDT3.
Modification :Unmodification
