Product Name :ARGLU1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Arginine and glutamate-rich protein 1: Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing . General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 . Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events . Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing . Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression . May also indirectly modulate alternative splicing . Regulates tra...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ARGLU1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Arginine and glutamate-rich protein 1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ARGLU1.
Modification :Unmodification
