Product Name :RNF25 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes . Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 . RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 . Also involved in ubiquitination and degradation of stalled ETF1/eRF1 . Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of RNF25 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :E3 ubiquitin-protein ligase RNF25; RING finger protein 25
Immunogen :A synthetic peptide encompassing a sequence within the center region of human RNF25.
Modification :Unmodification
