Product Name :TM4SF5 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Transmembrane 4 L6 family member 5: Acts as a lysosomal membrane arginine sensor . Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations . Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus . CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TM4SF5 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Transmembrane 4 L6 family member 5; Tetraspan transmembrane protein L6H
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TM4SF5.
Modification :Unmodification
