Product Name :CCDC88C polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Protein Daple: Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signaling . Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling . Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation . Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling . Promotes apical constriction of cells via ARHGEF18
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CCDC88C protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DAPLE; KIAA1509; Protein Daple; Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; Hook-related protein 2; HkRP2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CCDC88C.
Modification :Unmodification
