Product Name :ARPC4 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Actin-related protein 2/3 complex subunit 4: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ARPC4 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ARC20; Actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa subunit; p20-ARC
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ARPC4.
Modification :Unmodification
