Product Name :CHTOP polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Chromatin target of PRMT1 protein: Plays an important role in the ligand-dependent activation of estrogen receptor target genes . May play a role in the silencing of fetal globin genes . Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CHTOP protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C1orf77; FOP; Chromatin target of PRMT1 protein; Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CHTOP.
Modification :Unmodification
