Product Name :TMEM120A polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :Transmembrane protein 120A: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation . May function as a potential ion channel involved in sensing mechanical stimuli . Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction . TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism . Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TMEM120A protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :TMPIT; Transmembrane protein 120A; Transmembrane protein induced by tumor necrosis factor alpha
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TMEM120A.
Modification :Unmodification
