Product Name :CCDC25 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Coiled-coil domain-containing protein 25: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation . Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells . Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells . In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CCDC25 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Coiled-coil domain-containing protein 25
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CCDC25.
Modification :Unmodification
