Product Name :DOCK3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Dedicator of cytokinesis protein 3: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity)
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of DOCK3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0299; MOCA; Dedicator of cytokinesis protein 3; Modifier of cell adhesion; Presenilin-binding protein; PBP
Immunogen :A synthetic peptide encompassing a sequence within the center region of human DOCK3.
Modification :Unmodification
