Product Name :DHX15 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :ATP-dependent RNA helicase DHX15: RNA helicase involved in mRNA processing and antiviral innate immunity . Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA . In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns . Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome . Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) . Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by e...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of DHX15 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DBP1; DDX15; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; ATP-dependent RNA helicase 46; DEAH box protein 15
Immunogen :A synthetic peptide encompassing a sequence within the center region of human DHX15.
Modification :Unmodification
