Product Name :CNOT3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :CCR4-NOT transcription complex subunit 3: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of CNOT3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0691; LENG2; NOT3; CCR4-NOT transcription complex subunit 3; CCR4-associated factor 3; Leukocyte receptor cluster member 2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human CNOT3.
Modification :Unmodification
