Product Name :NRDE2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Nuclear exosome regulator NRDE2: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation . Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation . Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome . By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm . U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis . Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with rela...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of NRDE2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C14orf102; Protein NRDE2 homolog
Immunogen :A synthetic peptide encompassing a sequence within the center region of human NRDE2.
Modification :Unmodification
