Product Name :WDR24 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :GATOR2 complex protein WDR24: Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux . Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of WDR24 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :C16orf21; WD repeat-containing protein 24
Immunogen :A synthetic peptide encompassing a sequence within the center region of human WDR24.
Modification :Unmodification
