Product Name :SKIV2L polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Superkiller complex protein 2: Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways . The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation . SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling . In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) . May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SKIV2L protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :DDX13; SKI2W; SKIV2; W; Helicase SKI2W; Ski2; Helicase-like protein; HLP
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SKIV2L.
Modification :Unmodification
