Product Name :ECD polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :Protein ecdysoneless homolog: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP . May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes . Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins . The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex . May play a role in regulation of pre-mRNA splicing . Participates together with DDX39A in mRNA nuclear export
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ECD protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SGT1; Protein SGT1; hSGT1; Protein ecdysoneless homolog; Suppressor of GCR2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ECD.
Modification :Unmodification
