Product Name :ASXL3 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability . ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essen...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ASXL3 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1713; Putative Polycomb group protein ASXL3; Additional sex combs-like protein 3
Immunogen :A synthetic peptide encompassing a sequence within the N-terminal region of human ASXL3.
Modification :Unmodification
