Product Name :UVSSA polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000)
Background :UV-stimulated scaffold protein A: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes . Acts as a key adapter that promotes recruitment of factors involved in TC-NER . Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites . Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome . Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II . Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing rea...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of UVSSA protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1530; UV-stimulated scaffold protein A
Immunogen :A synthetic peptide encompassing a sequence within the center region of human UVSSA.
Modification :Unmodification
