Product Name :LRRC58 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Leucine-rich repeat-containing protein 58: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CDO1 . The ECS(LRRC58) complex acts as a regulator of cysteine catabolism by mediating ubiquitination and degradation of CDO1, the rate-limiting enzyme of the cysteine catabolic process to taurine . L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of LRRC58 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Leucine-rich repeat-containing protein 58
Immunogen :A synthetic peptide encompassing a sequence within the center region of human LRRC58.
Modification :Unmodification
