Product Name :TBC1D24 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :TBC1 domain family member 24: May act as a GTPase-activating protein for Rab family protein(s) . Involved in neuronal projection development, probably through negative modulation of ARF6 function . Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity . Involved in the regulation of synaptic vesicle trafficking . Promotes axonal outgrowth and membrane trafficking at the growth cone (By similarity). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (By similarity). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex . In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (By similarity...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TBC1D24 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1171; TBC1 domain family member 24
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TBC1D24.
Modification :Unmodification
