Product Name :MBD5 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Methyl-CpG-binding domain protein 5: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) . Important for stability of PR-DUB components and stimulating its ubiquitinase activity . As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 . The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability . MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways . Heterochromatin recruitment is not mediated by DNA methylation . The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferati...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of MBD5 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1461; Methyl-CpG-binding domain protein 5; Methyl-CpG-binding protein MBD5
Immunogen :A synthetic peptide encompassing a sequence within the center region of human MBD5.
Modification :Unmodification
