Product Name :WHAMM polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :WASP homolog-associated protein with actin, membranes and microtubules: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of WHAMM protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA1971; WHDC1; WASP homolog-associated protein with actin, membranes and microtubules; WAS protein homology region 2 domain-containing protein 1; WH2 domain-containing protein 1
Immunogen :A synthetic peptide encompassing a sequence within the center region of human WHAMM.
Modification :Unmodification
