Product Name :TSEN34 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :tRNA-splicing endonuclease subunit Sen34: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits functio...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TSEN34 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :LENG5; SEN34; tRNA-splicing endonuclease subunit Sen34; Leukocyte receptor cluster member 5; tRNA-intron endonuclease Sen34; HsSen34
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TSEN34.
Modification :Unmodification
