Product Name :FNIP2 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Folliculin-interacting protein 2: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 . Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 . Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 . Together with FLCN, regulates autophagy: following phosphorylation by ULK1...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of FNIP2 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FNIPL; KIAA1450; MAPO1; Folliculin-interacting protein 2; FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human FNIP2.
Modification :Unmodification
