Product Name :HERC1 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Probable E3 ubiquitin-protein ligase HERC1: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of HERC1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Probable E3 ubiquitin-protein ligase HERC1; HECT domain and RCC1-like domain-containing protein 1; p532; p619
Immunogen :A synthetic peptide encompassing a sequence within the center region of human HERC1.
Modification :Unmodification
