Product Name :IRGQ polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Immunity-related GTPase family Q protein: Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation . Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation . Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response . In contrast to other members of the family, does not show GTPase activity
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of IRGQ protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :IRGQ1; Immunity-related GTPase family Q protein
Immunogen :A synthetic peptide encompassing a sequence within the center region of human IRGQ.
Modification :Unmodification
